MUC1 and infection: For example, human adenovirus species C was identified as preferentially infecting a subset of goblet cells (19), enterovirus 71 infects goblet cell in 2D monolayer enteroids and reduces the expression of MUC-1 and MUC-2 (21), and PEDV infection leads to decreased numbers of goblet cells, and as a result, the intestinal mucus barrier is compromised, allowing other enteric pathogens to take advantage of the thinner mucus layer and establish infection (43, 44).