CCAAT enhancer binding protein beta (CEBPB), runt-related transcription factor 1 (RUNX-1), transforming growth factor-beta (TGF-β) receptor type 2 (TGFBR2), interferon-regulatory factor (IRF) 6, and IRF7 are important transcription factor–associated genes and showed similar expression patterns in AML cells and HAM relative to MDM (Fig. 4G). The gene discussed is IRF7; the disease is acute myeloid leukemia.