SCN8A and epilepsy: Indeed, genetic variations and secondary alterations of NaV1.6 have been implicated in neurological disorders, such as epilepsy, autism, intellectual disability, movement disorders and multiple sclerosis (Craner et al., 2004; Johannesen et al., 2022; Meisler et al., 2021), and auto-antibodies against NF186 have been found in patients with multiple sclerosis and chronic inflammatory demyelinating polyradiculoneuropathy (Kira et al., 2019).