CTH and neurodegenerative disease: However, a decrease in the expression of H2S producing enzyme (primarily CSE, but also CBS and MPST) and consequently the loss of persulfidation were found in aging and different age-induced diseases, such as neurodegenerative diseases (Giovinazzo et al., 2021; Petrovic et al., 2021; Snijder et al., 2015; Statzer et al., 2022; Zivanovic et al., 2019).