In Alzheimer's disease (AD), GSK3β phosphorylates tau protein (MAPT), leading to its dissociation from microtubules and increasing its propensity to aggregate, which results in the formation of neurofibrillary tangles, one of the most prominent features of the disease (Crews and Masliah, 2010; Hooper et al., 2008; Lauretti et al., 2020). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.