2022). Currently, the mechanism of organ injury in sepsis is ambiguous, which might be linked to the imbalance of inflammatory response, activation of the NF-κB pathway and oxygen free radical scavenging disorder (Li J et al. 2017; Li Y-M et al. 2019). Numerous studies have confirmed that TCM has unique advantages and broad prospects in the prevention and treatment of sepsis and organ damage (Zhao et al. 2019; Fan et al. 2020). As a significant component of TCM, PMS has been applied to remedy various inflammation-related diseases (Son et al. 2017; Liu F et al. 2019). The gene discussed is NFKB1; the disease is Sepsis.