Supplemental Figure 6, A–C shows that ectopic FOXM1 dramatically restored the RNF112-suppressed FOXM1 downstream genes. More interestingly, FOXM1 restoration also partially rescued RNF112-inhibited proliferation and invasion of gastric cancer (Supplemental Figure 6, D and E). Consistent with this finding, an obvious reversal of FOXM1 downstream genes, cell proliferation, and invasion were noticed in RNF112-depleted MGC803 cells after FOXM1 knockdown (Supplemental Figure 6, F–I). The gene discussed is FOXM1; the disease is gastric cancer.