APP and early-onset autosomal dominant Alzheimer disease: This hyperexcitability recapitulated the abnormalities observed in the APP transgenic mouse model of Alzheimer’s disease (mhAPP Swe/Ind J20 line)2,14 that were used to demonstrate that the endogenous production and trans-synaptic progression of Aβ along the performant pathway to the DG induces a rearrangement of inhibitory inputs to the DG cells leading to aberrant network activity.