It has been reported to play a role in modulating downstream therapeutic targets in glioblastoma tumour progression.36 The Endonuclease V, coded by the ENDOV gene, is a inosine-specific ribonuclease in RNA processing.37 Although its biological function remains unknown, haplotypes carrying p.R4810K in RNF213 have been reported to be in LD with ENDOV. The gene discussed is ENDOV; the disease is neoplasm.