Of note, a previous study of mutation genotypes of RNF213 gene from moyamoya patients in Taiwan reported clinical features of migraine or headache in 27.8% of patients.61 In summary, our results replicate the findings of previous studies for gene RNF213 and provide novel associations of gene ENDOV with broadly defined headache phenotype in the Han Chinese population. The gene discussed is RNF213; the disease is migraine disorder.