For broadly defined headache phenotype, an SNP cluster was identified in Chromosome 17 RNF213 gene region, of which five variants rs8078851, rs9674961, rs4890009, rs8080730 and rs4890010 are in high LD (R2 > 0.93) with the top SNP rs8072917 (with lowest P-value of 4.49 × 10−8) (Fig. 4A and Supplementary Table 2). Here, RNF213 is linked to Headache.