It has been reported to play a role in modulating downstream therapeutic targets in glioblastoma tumour progression.36 The Endonuclease V, coded by the ENDOV gene, is a inosine-specific ribonuclease in RNA processing.37 Although its biological function remains unknown, haplotypes carrying p.R4810K in RNF213 have been reported to be in LD with ENDOV. Here, RNF213 is linked to neoplasm.