Figure 2 depicts tissue-specific mACBP mRNA expression in insulin-sensitive tissues (i.e. liver and adipose tissue depots), as well as kidney and hypothalamus, in four groups of mice with different renal function, i.e. healthy, lean db/+ mice vs. endothelial dysfunctional eNOS-/- mice vs. obese, diabetic db/db mice with mild DKD vs. obese, diabetic eNOS-/-;db/db mice with severe DKD. This evidence concerns the gene INS and diabetic kidney disease.