KCNK2 and pulmonary arterial hypertension: In heterologous systems it has been shown that the presence of treprostinil (a tricyclic benzidine analogue of PGI2 used for treatment of pulmonary arterial hypertension) was able to inhibit TREK-1 and TREK-2, supporting the idea that TREK-1 could contribute to the cardiac mechano-electric feedback with a hyperpolarizing current in response to mechanical forces in the vascular system.