•Murine scRNA-seq datasets show the majority of infiltrating immune cells to be monocytes/macrophages•Functional enrichment, PPI analysis, and WGCNA of monocyte/macrophages pseudocells was performed on murine AAA scRNA-seq datasets to identify key functional pathways of Mo/Mø•DEG analysis of the two murine AAA datasets identified elevated expression of Thbs1, Il1b, and Clec4e, particularly within Mo/Mø. In the human AAA scRNA-seq database, these genes were also found to colocalize with CD68, a common macrophage marker. Here, CLEC4E is linked to triple-A syndrome.