MMP3 and triple-A syndrome: •5 subpopulations of immune cells were identified by t-distributed stochastic neighbor embedding (t-SNE), to which Mø expressed the highest percentage of necrotin-1 (Ntn1) positivity•Aneurysm Mø enriched with Ntn1 expressed high pro-inflammatory and angiogenic markers compared to Mø with low Ntn1 expression•Pathway analysis using DAVID software predicted crosstalk between netrin-1 and calcium signaling regulation, potentially linking macrophage secretion of netrin-1 to VSCM calcium flux and sequential production and activation of MMP3 within AAA