LRRK2 and Parkinson disease: Although the aetiology of PD in most patients is unclear, different pathological causes have been identified such as the accumulation of misfolded α-synuclein (α-Syn), the mutation of Leucine-rich repeat kinase 2 (LRRK2) and other impairment of mitochondrial function (Balestrino and Schapira 2020; Monfrini and Di Fonzo 2017; Schapira et al.1989).