CD4 and COVID-19: A well-resourced systematic review and meta-analysis of 22 studies, involving more than 20 million people living with HIV (PLWH) done in skilled tertiary setup showed that low CD4 count, high AIDS rate, and a high prevalence of multiple co-morbidities among PLWH with COVID-19 disease, seem to have a key role in the high COVID-19 mortality.