In studies on rats with diabetes mellitus (DM) induced by streptozotosin (STZ), it has been reported that follicle-stimulating hormone (FSH) synthesis, testosterone levels, and luteinizing hormone (LH) levels decreased owing to the negative effects of diabetes on the receptors (FSH, insulin, and insulin-like growth factor) of the seminiferous tubule [4]. This evidence concerns the gene INS and diabetes mellitus.