Among the compounds of DJD, Quercetin and Kaempferol are assigned a central position in the treatment of IDD because they form the densest associations with IDD-related targets and target crucial targets (such as AKT1, PIK3R1, TP53, CHUK, IGF-1, ERBB2, MYC, IL1B, and CAV1). Here, IGF1 is linked to intervertebral disk degenerative disorder.