SGCE is highly expressed in the cerebellum in mice and humans.[70, 71] Neuroimaging studies have also pointed to a phenotype‐related metabolic change in the parasagittal cerebellum in individuals with SGCE mutations.[74] Eyeblink conditioning (a paradigm of cerebellar‐dependent associative learning) is impaired in patients with SGCE‐related MDS, but not in those with isolated dystonia.[75, 76] In this paradigm, alcohol negatively affects performance in healthy individuals and improves it in patients with SGCE‐related MDS. This evidence concerns the gene SGCE and myelodysplastic syndrome.