SGCE and myelodysplastic syndrome: This constellation of clinical features has been noted for several decades.[61, 62] The first locus for MDS was mapped to the chromosomal region 7q21‐q31 more than 20 years ago.[63, 64, 65, 66] Sequencing the genes within this locus yielded the first causative gene, epsilon‐sarcoglycan (SGCE), whose heterozygous loss‐of‐function mutations segregate with MDS.[67]SGCE‐related MDS is typically inherited from the father, and there is a marked difference in the penetrance depending on the parental origin of the disease allele.