SGCE and Dystonia: However, a study reported that cerebellar Purkinje cell‐specific Sgce‐knockout mice did not exhibit the cardinal features of MDS, suggesting the involvement of other brain regions.[77] In contrast, adult mice with acute cerebellar Sgce knockdown showed the salient features of MDS, including myoclonus, dystonia, and alcohol responsiveness.[78] This discrepancy suggests the existence of some compensatory mechanisms in the previous model.[73]