PRRT2 and movement disorder: Therefore, it is not unexpected that monogenic childhood movement disorders, as exemplified by PRRT2‐related PKD and SGCE‐related MDS, are associated with electrophysiological abnormalities.[76, 104] A recent study demonstrated that mice with PRRT2 deletion in cerebellar granule cells are susceptible to the occurrence of a slowly propagating wave of depolarization in the cerebellar cortex (including granule cells and Purkinje cells).