SCN8A and myelodysplastic syndrome: In the past decade, several other genes have also been reported to be causative of MDS, although they were either challenged by later studies (e.g., CACNA1B) or are pending replication and validation (e.g., RELN).[80, 83, 84] Other genes, such as SCN8A, are associated with myoclonus and dystonia in some cases;[85] however, their overall presentations do not fit the typical clinical picture of MDS.