HSPA9 and even-plus syndrome: In the same year, EVEN-PLUS syndrome (EVPLS) was revealed to be caused by HSPA9 gene mutations (c.376C>T and 383A>G or 882-883delAG), which lead to amino acid substitution Arg126Trp, Tyr128Cys, or early termination, respectively (Royer-Bertrand et al. 2015).