NPPB and hydrops fetalis: While patients in the PARADIGM-HF study were ambulatory New York Hospital Association (NYHA) class II-III, those enrolled in the PIONEER-HF (Comparison of Sacubitril–Valsartan vs. Enalapril Effect on NT-proBNP in Patients Stabilized from an Acute HF Episode) were hospitalized with acute HF.