AGT and atrial fibrillation: The main results of the present study are as follows: 1) Lipidomics demonstrated the lipid profiles in patients with AF and identified PE as the differential lipid associated with AF; 2) In Ang II-induced mice, PE supplementation aggravated atrial fibrosis and increased peroxidation which could be alleviated by a ferroptosis inhibitor; 3) PE affected cardiomyocytes by promoting oxidation products and mitochondrial damage, which aggravated cardiomyocyte death induced by Ang II; 4) PE triggered ferroptosis in cardiomyocytes to participate in myocardium fibrosis (Figure 8).