Furthermore, FGF-21 attenuates atherosclerosis and inflammation in diet-induced obese ApoE-deficient rodents (Lin et al., 2015; Jia et al., 2018) and protects against cardiomyopathy and kidney disease in people with diabetes (Wu et al., 2017; Zhao et al., 2017). This evidence concerns the gene FGF21 and diabetes mellitus.