Other proteins, such as ROBO1, HUWE1, and CD14, are associated with fibrosis and dysfunction of the heart and kidney and are uniquely found in CRS urinary peptidome (Zhu et al., 2020; Liu et al., 2021; Petra et al., 2021; Sarohi et al., 2022b). The gene discussed is CD14; the disease is congenital rubella syndrome.