Mice received either a Chow or a High Fat-High Sucrose (HFHS) diet for 9 weeks to induce obesity Mice fed HFHS diet were then treated either with cranberry polyphenols (200 mg/kg) (HF+CP), Agavins (HF+AG), or the combination of CP and agavins (HF+CP+AG) for 9 weeks. The gene discussed is CP; the disease is obesity due to melanocortin 4 receptor deficiency.