The highest median serum HE4 level was observed in the patients with aLN (median, 85.5 pmol/L; IQR, 49.5–314.7) compared with the levels in the patients with cLN (median, 44 pmol/L; IQR, 38–63.8) and in those with aSLE without LN (median, 37 pmol/L; IQR, 30.5–50.6) as well as in the healthy controls (median, 30 pmol/L; IQR, 26.6–34.7) (Figure 1A). The gene discussed is WFDC2; the disease is lobular neoplasia.