Since no significant difference in serum HE4 level was found between the pure PLN (classes III and IV) and mixed PLN (classes III+V and IV+V) cases among all the aLN or cLN cases, or between the class III and class IV LN cases (Figures S1A–C), the patients demonstrating features of class III and IV LN concomitantly with features of class V LN were categorized as class III and class IV LN patients, respectively, in the subsequent analyses. This evidence concerns the gene WFDC2 and lobular neoplasia.