GSVA scoring of the above 13 gene signatures in GSE59867 (16) (n.patients: HF = 8, non-HF = 9, total of 32 HF samples, 36 non-HF samples) showed that eight of these genes were upregulated in HF relative to the non-HF sample for expression and found that four genes: HSPB1, ACTN1, STING1, and CCL5, were significant (Figure 5D, Supplementary Figure 8C). The gene discussed is HSPB1; the disease is hydrops fetalis.