The AUC values of hub genes were high in the combined dataset (GABARAPL2, AUC=0.988; USP8, AUC=0.94; RELA, AUC=0.927; SP1, AUC=0.894; and TBC1D17, AUC=0.927), implying that the five hub genes have high specificity for vitiligo and could be used as vitiligo diagnostic biomarkers. This evidence concerns the gene SP1 and vitiligo.