APOE and Alzheimer disease: In fact, recent studies have pointed out several neuropathological similarities of PASC Cognitive Syndrome with AD (26); including, numerous elevated AD marker genes (e.g., FERMT2, HLA-DRB1, GNA15, STAB1, ICA1L, COLGALT1, TNFAIP2, ITGAM, VASP, IDLIA, PVR, TECPR1) (39), several circulatory biomarkers (i.e. GFAP, NFL, P-tau 181, UCH, NSE, and S100B) (26), and the presence of Apolipoprotein E ε4 allele (APOE4) (40, 41), consistent with other reports (6).