Furthermore, tumor cells and innate immune cells in the TME also secrete chemokines that recruit T regulatory cells (CCL17/22, CCL5, CCL28 and CXCL9/10/11), expand T regulatory cells (TGF-β, IL-10), and convert conventional T cells into T regulatory cells (TGF-β and adenosine) (48). The gene discussed is TGFB1; the disease is neoplasm.