Contraindications to rhGH include pre-existing intracranial hypertension that could be worsened by rhGH, closed epiphyses, severe secondary hyperparathyroidism (PTH > 500pg/mL), proliferative or non-proliferative diabetic retinopathy, active malignancy, acute critical illness, within 1 year after renal transplantation, or known hypersensitivity to any component of rhGH medication (76). The gene discussed is PTH; the disease is secondary hyperparathyroidism.