KEAP1 and neoplasm: Besides, several other transcription factors or tumor suppressors, such as activating transcription factor 3 (ATF3), BRCA1 associated protein-1 (BAP1), ADP-ribosylation factor (ARF), and Kelch-like ECH-associated protein 1 (KEAP1), diminish the expression or suppress the activity of SLC7A11 to induce ferroptosis in cancer cells (Fan et al. 2017; Roh et al. 2017; Wang et al. 2020; Zhang et al. 2018b).