RELA and ependymoma: Pathological nuclear accumulation of p65-RELA subsequently occurs which represents the hallmark of ST-RELA-EPN tumors.8,9 The 3 complementary reports by Kupp et al. in 2021 provided important and novel insight into the molecular and cancer phenotype characteristics of ZFTAfus tumors.4–6 The management of ependymoma is evolving.