RELA and ependymoma: In line with these findings, Jünger et al. reported a 5-year OS of 92.6% and a 5-year PFS of 74.1% in a HIT ependymoma cohort of 54 patients with ZFTA-RELA fusion-positive ependymoma.9 Given these findings, it is possible that many patients with ZFTAfus ST-EPN are being over-treated.