Pathological nuclear accumulation of p65-RELA subsequently occurs which represents the hallmark of ST-RELA-EPN tumors.8,9 The 3 complementary reports by Kupp et al. in 2021 provided important and novel insight into the molecular and cancer phenotype characteristics of ZFTAfus tumors.4–6 The management of ependymoma is evolving. The gene discussed is RELA; the disease is cancer.