In their seminal paper, Pajtler et al. identified 9 molecular subgroups in a large cohort of 500 ependymal tumors.2 Within the supratentorial compartment, ependymomas can be driven by distinct gene fusions initially described as involving the NF-kB subunit RELA, c11orf- or the HIPPO signaling regulator YAP1. Here, RELA is linked to ependymoma.