RELA and supratentorial ependymoma: ZFTA-RELA fused supratentorial ependymoma (ZFTAfus ST-EPN) characterized by an oncogenic fusion between zinc finger translocation associated (ZFTA, formerly known as C11orf95) and in most cases v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA).3–6 Other alternative genes fused to ZFTA have been described in additional cases.5,7ZFTAfus ST-EPN, account for more than 70% of supratentorial ependymomas and primarily occur in children and young adults.