Pathological fibrils formed by different amyloid proteins are widely observed and commonly regarded as histopathological hallmarks of different neurodegenerative diseases (NDs), including α-synuclein (α-syn) in Parkinson’s disease (PD) (Baba et al.1998; Spillantini et al.1997), Tau and amyloid β (Aβ) in Alzheimer’s disease (AD) (Goedert et al.1988; Murphy and LeVine 2010), TAR DNA-binding protein 43 kDa (TDP-43) and fused in sarcoma (FUS) in amyotrophic lateral sclerosis (ALS) (Arai et al.2006). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.