In the only human study to date, exogenous full-length LEAP2 infusion in men without obesity, when fed to produce mildly supraphysiological plasma LEAP2 concentrations, acutely reduced food intake but not appetite ratings, supporting a stimulatory role of GHSR1a signaling on human food intake [13]. Here, GHSR is linked to obesity due to melanocortin 4 receptor deficiency.