In the 2020 WHO classification, ES is grouped with round cell sarcomas with EWSR1-nonerythroblast transformation specific (ETS) fusions, CIC-rearranged sarcomas, and sarcomas with BCOR genetic alterations in a new chapter named “undifferentiated small round cell sarcomas of bone and soft tissue” to represent a more accurate biological landscape (1). This evidence concerns the gene EWSR1 and sarcoma.