LIGHT-VTP alone induced TA-HEVs (20% of tumour) and significantly more CD3+ immune cells infiltration in tumours. Percentage of CD8+ T cells per tumour surface area and extent of GrzB expression was comparable to that of untreated tumoursCombined treatment significant increase in CD8+ T cells and an upregulation of GrzB expression. Significantly reduced tumour burden as compared to LIGHT-VTP treatment alone. This evidence concerns the gene CD8A and neoplasm.