Coulson-Gilmer et al. (Coulson-Gilmer et al. 2018) conducted multi-factor analysis on the age diagnosis, lymph node stage, tumor size, ER and PR status of male patients, and concluded that the expression of STC2 had a high upregulation in male breast cancer and STC2 can be used independently to diagnose disease-free survival. Here, ESR1 is linked to breast cancer.