While MMPs are connected to the malignant progression of several cancer types, including breast cancer, and MMPs-based cell migration has been demonstrated for 3D collagen fiber matrix assays (Zaman et al., 2006; Fraley et al., 2015; Hayn et al., 2020), the role of ADAM8 has not yet been explored in these 3D collagen fiber matrices. Here, ADAM8 is linked to cancer.