CRLF2 and acute lymphoblastic leukemia: TP53 and the three most frequently mutated genes in Ph-like B-ALL, CRLF2, IL7R, and JAK2 were wild-types (wts) in the analyzed samples (Roberts et al., 2014; Jain et al., 2017; Roberts, 2017; Iacobucci et al., 2021).