BCL2 and acute lymphoblastic leukemia: To investigate the changes occurring in the transcriptional program through the diverse disease stages and tissues in relationship with treatment responses, we analyzed the level of expression of BCL2-related genes and JAK/STAT pathway components in the patient’s samples (#1, #2, or #4) and compared it with 136 adult JAK1wt B-ALL cases, including 105 TN and 31 Ph + cases, and 15 healthy controls (Ctrls) (Supplementary Tables S1, S2).