Ltbp2 is involved in the TGFβ signaling pathway as it is required for the formation of the large latent complex (LLC) which binds latent TGFβ to the ECM (Munger et al., 1997) and is secreted by myofibroblasts in pulmonary fibrosis (Enomoto et al., 2018). This evidence concerns the gene LTBP2 and pulmonary fibrosis.