In the Pg sample, we observed interactions between ADM and CALCRL, which is related to periodontitis; EDA and EDA2R, which is related to ectodermal development; and SPP1 and CD44 and SPP1 and (ITGA4+ITGB1), which promotes phosphoprotein secretion and regulates bone salinization. This evidence concerns the gene SPP1 and periodontitis.