The upregulated Nos3, Socs1, and downregulated Pik3r1 inhibited the transduction of insulin receptor signaling, being associated with insulin resistance; the downregulated Acly inhibited the breakdown of citric acid, increasing energy production (Zhang et al., 2014; Piñeros Alvarez et al., 2017; Kempinska-Podhorodecka et al., 2019). The gene discussed is NOS3; the disease is Insulin resistance.