ClC-3 deletion caused the transcripted changes of 874 genes, a part of which was enriched in the glucose and lipid metabolism-related pathways, including steroid hormone biosynthesis, the PI3K-Akt signaling pathway, and regulation of lipolysis in adipocyte (Figure 3); 2540 DMR-anchored genes were partially clustered in the glucose metabolism-associated pathways, such as type II diabetes mellitus, insulin resistance, metabolic pathways, and citrate cycle (Figure 4). Here, CLCN3 is linked to type 2 diabetes mellitus.