ClC-3 deficiency attenuated hyperglycemia, hyperlipidemia, and insulin resistance in type 2 diabetes mellitus (Huang et al., 2014), and it ameliorated high-fat diet-induced obesity, which promoted the development of glucose and lipid metabolism disorders (Ma et al., 2019). This evidence concerns the gene CLCN3 and obesity due to melanocortin 4 receptor deficiency.