The upregulated Nos3, Socs1, and downregulated Pik3r1 inhibited the transduction of insulin receptor signaling, being associated with insulin resistance; the downregulated Acly inhibited the breakdown of citric acid, increasing energy production (Zhang et al., 2014; Piñeros Alvarez et al., 2017; Kempinska-Podhorodecka et al., 2019). This evidence concerns the gene PIK3R1 and Insulin resistance.