MAPT and tauopathy: Specifically, related to AD, it has been reported that (i) both brains of AD patients [21–23] and those of P301S mice, a mouse model overexpressing mutated tau protein and reproduces the AD-associated Tauopathy, present elevated P2X7R expression levels [24–27], (ii) P2X7R is a major driver of neuroinflammation [21, 22], and (iii) is involved in neuronal death [28, 29] associated with AD.