TYRP1 and non-small cell lung carcinoma: As shown in Fig. 3B, the levels of mature-CatB 、mature-CatD and mature-CatL at protein expression were reduced both in NCI-H1299 and A549 in a dose-and time-dependent manner, collectively demonstrating that FJHQ disturbs autophagy by inhibiting lysosomal cathepsin maturity in NSCLC cells.