Befitting any general immune response mechanism, various cytokines may potentially modulate ICAM1 expression, of which we have found evidence for statistical association of IL1, IL4 (and its receptor, IL4R), IL6, IL13, TLR2, TLR4, and IFNG (and its receptor, IFNGR1) polymorphisms with malaria. The gene discussed is TLR4; the disease is malaria.