Notably, gene sets for cytokine receptor activity and binding (Fig. 3A, B), tumor necrosis factor (TNF) superfamily cytokine production (Fig. 3C, D), positive regulation of IL-6 production (Fig. 3E, F), and the IL-1 pathway (Fig. 3G) were significantly enriched in FFAR2DownTLR2UpTLR3Up NSCLC (Group A) vs. FFAR2UpTLR2DownTLR3Down NSCLC (Group B). Here, IL1B is linked to non-small cell lung carcinoma.