Moreover, GSEA between FFAR2DownTLR2UpTLR3Up LTTs and FFAR2UpTLR2DownTLR3Down LTTs of NSCLC patients revealed significant enrichments in the cancer module, innate signaling pathways, and cytokine-chemokines gene sets in FFAR2DownTLR2UpTLR3Up LTTs, suggesting a functional association between FFAR2 and TLR2 or TLR3 in lung cancer. Here, TLR3 is linked to lung cancer.