In terms of biochemical mechanisms, NF-κB activation by the engagement of TLRs plays a pivotal role in cancer proliferation, survival, angiogenesis, and progression through the up-regulation of IL-6, Bcl-xL, Bcl-2, Bcl-xs, XIAP, and VEGF genes [20, 23, 54]. This evidence concerns the gene BCL2L1 and cancer.