For instance, using data from K562 cell line, we show the recovery of a large-scale enhancer regulatory network, depending on HDAC2 and GATA1 rescued peaks, whose components are involved in Chronic Myeloid Leukemia (CML) and several cancer-associated processes [11–16]. The gene discussed is HDAC2; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.