C-X-C motif chemokine receptor 4 and its only known ligand SDF1 are crucially involved in stem cell mobilization and migration of CXCR4-positive bone marrow (BM) cells by following a gradient towards (neo-)angiogenic niches, finally leading to promotion of tumor-feeding vessels and metastatic spread [1]. This evidence concerns the gene CXCR4 and neoplasm.