In addition, the knockdown of ATF5 using AAV9 system (sh-ATF5) in adult mice hearts (Supplementary Fig. 7c) promoted cardiomyocytes proliferation, improved cardiac function and reduced infarct size in MI-injured hearts (Fig. 6g and Supplementary Fig. 7d, e), indicating that ATF5 is involved in the regulation of cardiomyocyte proliferation and cardiac regeneration. The gene discussed is ATF5; the disease is myocardial infarction.