Meanwhile, the numbers of Ki67-positive, pH3-positive, and Aurora B-positive cells were higher in TMEM11 KO hearts after MI injury (Fig. 3c–f), which suggest that depletion of TMEM11 improved myocardial repair and cardiac function after MI injury by inducing cardiomyocyte proliferation. This evidence concerns the gene MKI67 and myocardial infarction.