TMEM11 and myocardial infarction: TMEM11 KO significantly reduced scar size compared to that in WT hearts (Fig. 3a), and the left ventricle function was improved in TMEM11 KO mice after MI (Fig. 3b, Supplementary Fig. 4b, c), indicating that TMEM11 silencing mediates the reparative potential of cardiomyocytes after cardiac injury.