PZH could significantly inhibit the activation of PI3K/AKT signaling pathway, VEFG-C secretion of colorectal cancer cells, and the cancer cells’ supernatant with PZH treatment could inhibit the VEGFR3 expression, PI3K/AKT pathway activation, MMPs expression and lymphangiogenesis of HLECs. This evidence concerns the gene FLT4 and colorectal cancer.