LYVE1 and neoplasm: The effect of PZH on the expression of VEGF-C, VEGFR-3, and LYVE-1 was detected using IHC in two kinds of animal models, which showed that PZH significantly reduced the expression of LYVE-1, VEGF-C, and VEGFR-3 in subcutaneous xenograft tumor tissues and orthotopic xenograft tumor tissues (P < 0.01) (Fig. 3A, D).