CDKN2B-AS1 and cancer: To find a reliable target of PZH to inhibit colorectal cancer metastasis, and provide a key experimental basis for the clinical use of PZH, we combining the research of ANRIL function with PZH pharmacodynamics, via two tumor-bearing models, colorectal cancer cells model with differential expression of ANRIL, simulating the regulation of cancer cells on HLECs in vitro, and rescue experiments.