Combining with the previous studies, the reason maybe the overexpression of ANRIL promote the VEGF-C secretion of cancer cells by activating PI3K/AKT pathway, and the VEGF-C in supernatant stimulate the VEGFR3 expression, PI3K/AKT pathway activation, MMPs expression and lymphangiogenesis of HLECs. The gene discussed is CDKN2B-AS1; the disease is cancer.