TP53 and familial pancreatic carcinoma: Interestingly, many of these pathways/functions are known to play a role in pancreatic cancer: p53 is often mutated in PDAC36, perturbation of the DNA damage response and DNA replication have been characterized in a variety of cancers, including PDAC37–39, and pancreatic cancer stem cells rely on intact lysosomes for their survival40.