A signaling molecule binds to the G-protein-coupled bile acid receptor 1 (GPBAR1 or TGR5), which regulates hepatic steatosis and the inflammatory response, and activates the expression of the FXR; this then controls the balance of energy metabolism, controls hepatic steatosis and the inflammatory response, and influences the composition of the intestinal tract. The gene discussed is NR1H4; the disease is Hepatic steatosis.